MolNFT v1 · #182411 · protein
Crystal structure of cytosolic hppk-dhps from A.THALIANA
7MPY · Folate synthesis bifunctional protein: “Crystal structure of cytosolic hppk-dhps from A.THALIANA”. X-ray diffraction, 12 pockets (best druggability 0.78). MolNFT v1 #182411 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7MPY
- Type
- protein
- Length
- 853 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Folate synthesis bifunctional protein
- EC
- 2.7.6.3, 2.5.1.15
- UniProt
- Q1ENB6
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Folate synthesis bifunctional protein (EC 2.7.6.3, 2.5.1.15) | protein | 423 | 46% helix, 21% strand | Q1ENB6 |
| B | Folate synthesis bifunctional protein (EC 2.7.6.3, 2.5.1.15) | protein | 430 | 44% helix, 19% strand | Q1ENB6 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 669 | 0.78 | 0.83 | 69 | empty |
| 2 | 521 | 0.70 | 0.80 | 69 | empty |
| 3 | 423 | 0.66 | 0.79 | 57 | empty |
| 4 | 270 | 0.57 | 0.78 | 36 | empty |
| 5 | 147 | 0.52 | 0.80 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 999 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 7MPY · Crystal structure of cytosolic HPPK-DHPS from A.thaliana · the same entry in another collection · chain A against A, TM-score 1.00
- Q1ENB6 · AlphaFold monomer V2.0 prediction for folate synthesis bifunctional protein (Q1ENB6) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1ENB6
- Elsewhere: RCSB PDB 7MPY · PDBe 7MPY · UniProt Q1ENB6
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