MolNFT v1 · #182408 · protein

Cmcc from type II cut mcp

7MPV · Bmc domain-containing protein: “Cmcc from type II cut mcp”. X-ray diffraction, 6 pockets (best druggability 0.64). MolNFT v1 #182408 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7MPV
Type: protein
Length: 1,031 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bmc domain-containing protein
UniProt: Q8G9V7
Pockets: 6 · best druggability 0.64

Structure

x-ray diffraction · 11 distinct chains · 37% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bmc domain-containing protein	protein	85	38% helix, 36% strand	Q8G9V7
B	Bmc domain-containing protein	protein	88	36% helix, 35% strand	Q8G9V7
C	Bmc domain-containing protein	protein	80	40% helix, 41% strand	Q8G9V7
D	Bmc domain-containing protein	protein	88	36% helix, 35% strand	Q8G9V7
E	Bmc domain-containing protein	protein	89	36% helix, 37% strand	Q8G9V7
F	Bmc domain-containing protein	protein	91	35% helix, 36% strand	Q8G9V7
G	Bmc domain-containing protein	protein	92	35% helix, 36% strand	Q8G9V7
H, J	Bmc domain-containing protein	protein	84	38% helix, 37% strand	Q8G9V7
I	Bmc domain-containing protein	protein	81	40% helix, 38% strand	Q8G9V7
K	Bmc domain-containing protein	protein	84	38% helix, 37% strand	Q8G9V7
L	Bmc domain-containing protein	protein	85	38% helix, 36% strand	Q8G9V7

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	602	0.64	0.75	57	empty
2	154	0.46	0.75	23	empty
3	127	0.39	0.75	24	empty
4	132	0.38	0.74	24	empty
5	89	0.36	0.75	11	empty

Interfaces

14 interfaces between chains.

G–H · 1060 Å² buried · 16 hydrogen bonds · protein-protein
D–F · 1000 Å² buried · 14 hydrogen bonds · protein-protein
C–D · 886 Å² buried · 17 hydrogen bonds · protein-protein
B–E · 827 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 824 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

7MPV · CmcC from Type II Cut MCP · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8G9V7
Elsewhere: RCSB PDB 7MPV · PDBe 7MPV · UniProt Q8G9V7

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