MolNFT v1 · #18225 · protein

Yeast actin interacting protein 1 (AIP1), orthorhombic crystal form

1PI6: “Yeast actin interacting protein 1 (AIP1), orthorhombic crystal form”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability 0.75). MolNFT v1 #18225 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1PI6
Type: protein
Length: 606 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actin interacting protein 1
UniProt: P46680
Ligands: ZN
Pockets: 5 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 1% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Actin interacting protein 1	protein	606	1% helix, 53% strand	P46680

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	707	0.75	0.81	60	empty
2	422	0.73	0.84	43	empty
3	294	0.66	0.82	38	empty
4	374	0.59	0.76	57	empty
5	75	0.31	0.74	17	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1PI6 · YEAST ACTIN INTERACTING PROTEIN 1 (Aip1), ORTHORHOMBIC CRYSTAL FORM · the same entry in another collection · chain A against A, TM-score 1.00
P46680 · AlphaFold monomer V2.0 prediction for actin-interacting protein 1 (P46680) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46680
Elsewhere: RCSB PDB 1PI6 · PDBe 1PI6 · UniProt P46680

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