MolNFT v1 · #182222 · protein
Straight tau filament extracted from prp-caa patient brain tissue | tau filament | sf tau
7MKG · Isoform tau-F of microtubule-associated protein tau: “Straight tau filament extracted from prp-caa patient brain tissue | tau filament | sf tau”. Electron microscopy, 7 pockets (best druggability 0.63). MolNFT v1 #182222 on…
- PDB
- 7MKG
- Type
- protein
- Length
- 730 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform tau-F of microtubule-associated protein tau
- Pockets
- 7 · best druggability 0.63
Structure
electron microscopy · 1 distinct chain · 0% helix, 67% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E, F, C, D, G, H, I, J | Isoform tau-F of microtubule-associated protein tau | protein | 73 | 0% helix, 67% strand | — |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.63 | 0.92 | 25 | empty |
| 2 | 356 | 0.62 | 0.78 | 43 | empty |
| 3 | 66 | 0.60 | 0.90 | 24 | empty |
| 4 | 60 | 0.59 | 0.91 | 25 | empty |
| 5 | 212 | 0.56 | 0.80 | 36 | empty |
Interfaces
23 interfaces between chains.
- G–I · 3090 Ų buried · 85 hydrogen bonds · protein-protein
- A–E · 3088 Ų buried · 85 hydrogen bonds · protein-protein
- C–G · 3086 Ų buried · 84 hydrogen bonds · protein-protein
- E–C · 3085 Ų buried · 85 hydrogen bonds · protein-protein
- H–J · 3069 Ų buried · 83 hydrogen bonds · protein-protein
Compared structures
- 7MKG · Straight tau filament extracted from PrP-CAA Patient brain tissue | tau filament | SF Tau · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7MKG · PDBe 7MKG
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