MolNFT v1 · #182221 · protein

Paired helical filament extracted from prp-caa patient brain tissue

7MKF · Isoform tau-F of microtubule-associated protein tau: “Paired helical filament extracted from prp-caa patient brain tissue”. Electron microscopy, 3 pockets (best druggability 0.53). MolNFT v1 #182221 on GenesisL1: 3D structure…

PDB: 7MKF
Type: protein
Length: 730 residues
Chains: 10
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform tau-F of microtubule-associated protein tau
Pockets: 3 · best druggability 0.53

Structure

electron microscopy · 1 distinct chain · 0% helix, 66% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J	Isoform tau-F of microtubule-associated protein tau	protein	73	0% helix, 66% strand	—

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	202	0.53	0.77	28	empty
2	206	0.52	0.77	30	empty
3	87	0.32	0.73	22	empty

Interfaces

27 interfaces between chains.

F–H · 3118 Å² buried · 94 hydrogen bonds · protein-protein
D–F · 3117 Å² buried · 94 hydrogen bonds · protein-protein
B–D · 3116 Å² buried · 94 hydrogen bonds · protein-protein
H–J · 3115 Å² buried · 94 hydrogen bonds · protein-protein
A–C · 3065 Å² buried · 87 hydrogen bonds · protein-protein

Compared structures

7MKF · Paired helical tau filament extracted from PrP-CAA Patient brain tissue | tau filament |… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7MKF · PDBe 7MKF

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