MolNFT v1 · #182213 · protein

Augmentor domain of augmentor-beta

7MK7 · ALK and ltk ligand 1,MALTODEXTRIN-binding protein: “Augmentor domain of augmentor-beta”. X-ray diffraction, 1 ligand (GLC), 2 pockets (best druggability 0.70). MolNFT v1 #182213 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7MK7
Type: protein
Length: 737 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ALK and ltk ligand 1,MALTODEXTRIN-binding protein
UniProt: Q6UXT8, A0A2Y0TBT9
Ligands: GLC
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ALK and ltk ligand 1,MALTODEXTRIN-binding protein	protein	369	46% helix, 17% strand	Q6UXT8, A0A2Y0TBT9
B	ALK and ltk ligand 1,MALTODEXTRIN-binding protein	protein	368	48% helix, 18% strand	Q6UXT8, A0A2Y0TBT9

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	297	0.70	0.84	26	GLC
2	263	0.67	0.83	26	GLC

Interfaces

1 interface between chains.

A–B · 809 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7MK7 · Augmentor domain of augmentor-beta · the same entry in another collection · chain A against A, TM-score 1.00
Q6UXT8 · AlphaFold monomer V2.0 prediction for ALK and ltk ligand 1 (Q6UXT8) · a predicted model of the same protein · chain A against A, TM-score 0.13

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6UXT8
Every structure of UniProt A0A2Y0TBT9
Elsewhere: RCSB PDB 7MK7 · PDBe 7MK7 · UniProt Q6UXT8 · UniProt A0A2Y0TBT9

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