MolNFT v1 · #182212 · protein

Kcsa open gate E71V mutant with sodium

7MK6 · Fab heavy chain: “Kcsa open gate E71V mutant with sodium”. X-ray diffraction, 4 pockets (best druggability 0.59). MolNFT v1 #182212 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7MK6
Type: protein
Length: 495 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab heavy chain; Fab light chain; PH-gated potassium channel kcsa
UniProt: P0A334
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 3 distinct chains · 17% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fab heavy chain	protein	209	4% helix, 39% strand	—
B	Fab light chain	protein	195	5% helix, 38% strand	—
C	PH-gated potassium channel kcsa	protein	91	71% helix, 0% strand	P0A334

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.59	0.89	24	empty
2	423	0.55	0.73	47	empty
3	130	0.40	0.75	28	empty
4	83	0.31	0.73	20	empty

Interfaces

3 interfaces between chains.

A–B · 1681 Å² buried · 17 hydrogen bonds · protein-protein
A–C · 455 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 392 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7MK6 · KcsA open gate E71V mutant with sodium · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A334
Elsewhere: RCSB PDB 7MK6 · PDBe 7MK6 · UniProt P0A334

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