MolNFT v1 · #182050 · protein

Crystal structure of antibody 10E8V4 Fab - light chain H31F variant

7MFB · Antibody 10E8V4 Fab heavy chain: “Crystal structure of antibody 10E8V4 Fab - light chain H31F variant”. X-ray diffraction, 5 pockets (best druggability 0.66). MolNFT v1 #182050 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7MFB
Type: protein
Length: 442 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antibody 10E8V4 Fab heavy chain; Antibody 10E8V4 Fab light chain
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Antibody 10E8V4 Fab heavy chain	protein	232	9% helix, 50% strand	—
L	Antibody 10E8V4 Fab light chain	protein	210	9% helix, 52% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	682	0.66	0.75	64	empty
2	113	0.49	0.81	26	empty
3	112	0.36	0.74	20	empty
4	64	0.29	0.74	23	empty
5	52	0.25	0.73	17	empty

Interfaces

1 interface between chains.

H–L · 1974 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7MFB · Crystal structure of antibody 10E8v4 Fab - light chain H31F variant · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7MFB · PDBe 7MFB

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