MolNFT v1 · #182049 · protein
Crystal structure of antibody 10E8V4-P100FA+P100GA Fab
7MFA · Antibody 10E8V4 Fab heavy chain: “Crystal structure of antibody 10E8V4-P100FA+P100GA Fab”. X-ray diffraction, 20 pockets (best druggability 0.73). MolNFT v1 #182049 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MFA
- Type
- protein
- Length
- 2,599 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody 10E8V4 Fab heavy chain; Antibody 10E8V4 Fab light chain
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 6 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Antibody 10E8V4 Fab heavy chain | protein | 224 | 4% helix, 52% strand | — |
| L, D, N, R, V | Antibody 10E8V4 Fab light chain | protein | 209 | 9% helix, 50% strand | — |
| C | Antibody 10E8V4 Fab heavy chain | protein | 225 | 7% helix, 51% strand | — |
| G, M, U | Antibody 10E8V4 Fab heavy chain | protein | 224 | 4% helix, 50% strand | — |
| I | Antibody 10E8V4 Fab light chain | protein | 210 | 8% helix, 50% strand | — |
| Q | Antibody 10E8V4 Fab heavy chain | protein | 223 | 7% helix, 52% strand | — |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 439 | 0.73 | 0.83 | 61 | empty |
| 2 | 367 | 0.72 | 0.84 | 38 | empty |
| 3 | 586 | 0.65 | 0.76 | 66 | empty |
| 4 | 576 | 0.64 | 0.75 | 55 | empty |
| 5 | 533 | 0.60 | 0.74 | 52 | empty |
Interfaces
22 interfaces between chains.
- H–L · 1892 Ų buried · 14 hydrogen bonds · protein-protein
- M–N · 1890 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 1876 Ų buried · 15 hydrogen bonds · protein-protein
- Q–R · 1851 Ų buried · 10 hydrogen bonds · protein-protein
- U–V · 1819 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide (disulfide).
Compared structures
- 7MFA · Crystal structure of antibody 10E8v4-P100fA+P100gA Fab · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7MFA · PDBe 7MFA
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