MolNFT v1 · #182046 · protein

Crystal structure of antibody 10E8V4-P100GA Fab

7MF7 · Antibody 10E8V4 Fab heavy chain: “Crystal structure of antibody 10E8V4-P100GA Fab”. X-ray diffraction, 18 pockets (best druggability 0.80). MolNFT v1 #182046 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7MF7
Type: protein
Length: 1,736 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antibody 10E8V4 Fab heavy chain; Antibody 10E8V4 Fab light chain
Pockets: 18 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H, A, C, E	Antibody 10E8V4 Fab heavy chain	protein	224	8% helix, 51% strand	—
L, B, D, F	Antibody 10E8V4 Fab light chain	protein	210	8% helix, 50% strand	—

Pockets

18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	726	0.80	0.84	60	empty
2	681	0.72	0.79	83	empty
3	165	0.59	0.83	28	empty
4	343	0.58	0.76	46	empty
5	317	0.54	0.74	42	empty

Interfaces

15 interfaces between chains.

E–F · 2052 Å² buried · 25 hydrogen bonds · protein-protein
H–L · 1991 Å² buried · 25 hydrogen bonds · protein-protein
A–B · 1987 Å² buried · 18 hydrogen bonds · protein-protein
C–D · 1969 Å² buried · 21 hydrogen bonds · protein-protein
A–C · 746 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

7MF7 · Crystal structure of antibody 10E8v4-P100gA Fab · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7MF7 · PDBe 7MF7

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