MolNFT v1 · #18181 · protein

2:2 complex of G-csf with its receptor

1PGR · Protein (granulocyte colony-stimulating factor): “2:2 complex of G-csf with its receptor”. X-ray diffraction, 14 pockets (best druggability 0.62). MolNFT v1 #18181 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1PGR
Type: protein
Length: 1,471 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (granulocyte colony-stimulating factor); Protein (G-csf receptor)
UniProt: P09919, P40223
Pockets: 14 · best druggability 0.62

Structure

x-ray diffraction · 6 distinct chains · 34% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (granulocyte colony-stimulating factor)	protein	161	69% helix, 1% strand	P09919
B	Protein (G-csf receptor)	protein	208	6% helix, 46% strand	P40223
C, G	Protein (granulocyte colony-stimulating factor)	protein	165	69% helix, 0% strand	P09919
D, H	Protein (G-csf receptor)	protein	200	6% helix, 46% strand	P40223
E	Protein (granulocyte colony-stimulating factor)	protein	163	68% helix, 1% strand	P09919
F	Protein (G-csf receptor)	protein	209	6% helix, 45% strand	P40223

Pockets

14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.62	0.94	15	empty
2	56	0.61	0.92	19	empty
3	340	0.58	0.76	34	empty
4	260	0.55	0.77	33	empty
5	242	0.53	0.76	31	empty

Interfaces

8 interfaces between chains.

E–F · 819 Å² buried · 11 hydrogen bonds · protein-protein
G–H · 812 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 803 Å² buried · 10 hydrogen bonds · protein-protein
C–D · 785 Å² buried · 9 hydrogen bonds · protein-protein
A–D · 330 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 28 disulfide (disulfide).

Compared structures

1PGR · 2:2 complex of G-csf with its receptor · the same entry in another collection · chain H against H, TM-score 1.00
P40223 · AlphaFold monomer V2.0 prediction for granulocyte colony-stimulating factor receptor… · a predicted model of the same protein · chain H against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09919
Every structure of UniProt P40223
Elsewhere: RCSB PDB 1PGR · PDBe 1PGR · UniProt P09919 · UniProt P40223

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