MolNFT v1 · #181758 · protein

Menin bound to M-1121

7M4T: “Menin bound to M-1121”. X-ray diffraction, 2 ligands (7PR, YQV). MolNFT v1 #181758 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7M4T
Type: protein
Length: 481 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O00255
Ligands: 7PR, YQV

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	481	—	O00255

Ligands and binding sites

7PR · praseodymium triacetate · ligand · 5 copies · chains A
YQV · methyl {(1S,2R)-2-[(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-{1-[(3-methoxy-1-{4-[(1S,4S)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptane-2-sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}ethyl]cyclopentyl}carbamate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7M4T · Menin bound to M-1121 · the same entry in another collection · chain A against A, TM-score 1.00
O00255 · AlphaFold monomer V2.0 prediction for menin (O00255) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00255
Elsewhere: RCSB PDB 7M4T · PDBe 7M4T · UniProt O00255

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