MolNFT v1 · #181627 · protein

Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments

7M0G: “Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments”. Solid-state nmr, 2 pockets (best druggability 0.60). MolNFT v1 #181627 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7M0G
Type: protein
Length: 166 residues
Chains: 1
Method: solid-state nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cofilin-2
UniProt: Q9Y281
Pockets: 2 · best druggability 0.60

Structure

solid-state nmr · 1 distinct chain · 34% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cofilin-2	protein	166	34% helix, 25% strand	Q9Y281

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	126	0.60	0.85	31	empty
2	61	0.34	0.78	15	empty

Compared structures

7M0G · Magic Angle Spinning NMR Structure of Human Cofilin-2 Assembled on Actin Filaments · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y281 · AlphaFold monomer V2.0 prediction for cofilin-2 (Q9Y281) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y281
Elsewhere: RCSB PDB 7M0G · PDBe 7M0G · UniProt Q9Y281

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