MolNFT v1 · #18154 · protein

Methionyl-tRNA synthetase from escherichia COLI complexed with trifluoromethionine

1PFW: “Methionyl-tRNA synthetase from escherichia COLI complexed with trifluoromethionine”. X-ray diffraction, 2 ligands (MF3, ZN), 2 pockets (best druggability 0.64). MolNFT v1 #18154 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1PFW
Type: protein
Length: 546 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methionyl-tRNA synthetase
EC: 6.1.1.10
UniProt: P00959
Ligands: MF3, ZN
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methionyl-tRNA synthetase (EC 6.1.1.10)	protein	546	51% helix, 16% strand	P00959

Ligands and binding sites

MF3 · 2-amino-4-trifluoromethylsulfanyl-butyric acid · ligand · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	337	0.64	0.79	32	MF3
2	246	0.56	0.77	42	empty

Compared structures

1PFW · Methionyl-tRNA synthetase from escherichia COLI complexed with trifluoromethionine · the same entry in another collection · chain A against A, TM-score 1.00
P00959 · AlphaFold monomer V2.0 prediction for methionine--tRNA ligase (P00959) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00959
Elsewhere: RCSB PDB 1PFW · PDBe 1PFW · UniProt P00959

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.