MolNFT v1 · #181529 · protein

Crystal structure of human CYP3A4 bound to the testosterone dimer

7LXL: “Crystal structure of human CYP3A4 bound to the testosterone dimer”. X-ray diffraction, 2 ligands (HEM, YNV). MolNFT v1 #181529 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LXL
Type: protein
Length: 453 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P08684
Ligands: HEM, YNV

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	453	—	P08684

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
YNV · 17alpha-hydroxy-7alpha-[(2Z)-4-(17beta-hydroxy-3-oxo-8alpha-androst-4-en-7beta-yl)but-2-en-1-yl]-8alpha, 10alpha,13alpha,14beta-androst-4-en-3-one · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7LXL · Crystal structure of human CYP3A4 bound to the testosterone dimer · the same entry in another collection · chain A against A, TM-score 1.00
P08684 · AlphaFold monomer V2.0 prediction for cytochrome P450 3A4 (P08684) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08684
Elsewhere: RCSB PDB 7LXL · PDBe 7LXL · UniProt P08684

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.