Crystal structure of S-adenosylmethionine-dependent methyltransferase umaa from mycobacterium tuberculosis in complex with sah

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 16% strand (DSSP).

Ligands and binding sites

• SAH · S-adenosyl-L-homocysteine · ligand · chains A
• NO3 · Nitrate ion · ion · 2 copies · chains A
• PO4 · Phosphate ion · ion · chains A
• CL · Chloride ion · ion · chains A
• P6G · Hexaethylene glycol · additive · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 7LXI · Crystal structure of S-adenosylmethionine-dependent methyltransferase UmaA from… · the same entry in another collection · chain A against A, TM-score 1.00
• Q6MX39 · AlphaFold monomer V2.0 prediction for S-adenosylmethionine-dependent methyltransferase… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q6MX39
• Elsewhere: RCSB PDB 7LXI · PDBe 7LXI · UniProt Q6MX39