MolNFT v1 · #181468 · protein

Structure of rsv F-directed vhh CL184

7LVU · F-vhh-CL184: “Structure of rsv F-directed vhh CL184”. X-ray diffraction, 6 pockets (best druggability 0.60). MolNFT v1 #181468 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LVU
Type: protein
Length: 490 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: F-vhh-CL184
Pockets: 6 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	F-vhh-CL184	protein	122	10% helix, 51% strand	—
B, D	F-vhh-CL184	protein	123	7% helix, 50% strand	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.60	0.90	24	empty
2	250	0.51	0.75	26	empty
3	226	0.49	0.75	34	empty
4	170	0.46	0.76	26	empty
5	155	0.44	0.75	28	empty

Interfaces

5 interfaces between chains.

B–D · 508 Å² buried · 13 hydrogen bonds · protein-protein
A–C · 489 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 328 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 157 Å² buried · 5 hydrogen bonds · protein-protein
C–D · 153 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7LVU · Structure of RSV F-directed VHH Cl184 · the same entry in another collection · chain D against D, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7LVU · PDBe 7LVU

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