MolNFT v1 · #181467 · protein

Structure of full-length GLUK1 with L-glu

7LVT · Isoform GLUR5-2 of glutamate receptor ionotropic, kainate 1: “Structure of full-length GLUK1 with L-glu”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #181467 on GenesisL1: 3D structure, binding sites and…

PDB: 7LVT
Type: protein
Length: 2,876 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform GLUR5-2 of glutamate receptor ionotropic, kainate 1
Pockets: 20 · best druggability 0.81

Structure

electron microscopy · 1 distinct chain · 42% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Isoform GLUR5-2 of glutamate receptor ionotropic, kainate 1	protein	719	42% helix, 18% strand	—

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	973	0.81	0.82	125	empty
2	1154	0.80	0.82	149	empty
3	1079	0.80	0.82	133	empty
4	724	0.80	0.84	108	empty
5	856	0.77	0.81	82	empty

Interfaces

5 interfaces between chains.

A–B · 2202 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 2147 Å² buried · 8 hydrogen bonds · protein-protein
B–D · 674 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 570 Å² buried · 1 hydrogen bond · protein-protein
A–D · 451 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7LVT · Structure of full-length GluK1 with L-Glu · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7LVT · PDBe 7LVT

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