MolNFT v1 · #181432 · protein
Stable effector functionless 2 (SEFL2) IGG1 Fc scaffold bound to a minimized version of the B-domain (mini-Z) from protein a called Z34C
7LUR · Immunoglobulin heavy constant gamma 1: “Stable effector functionless 2 (SEFL2) IGG1 Fc scaffold bound to a minimized version of the B-domain (mini-Z)…”. X-ray diffraction, 2 pockets (best druggability 0.31). MolNFT v1 #181432 on…
- PDB
- 7LUR
- Type
- protein
- Length
- 482 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin heavy constant gamma 1; Mini Z domain
- UniProt
- P01857
- Pockets
- 2 · best druggability 0.31
Structure
x-ray diffraction · 2 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Immunoglobulin heavy constant gamma 1 | protein | 207 | 10% helix, 48% strand | P01857 |
| C, D | Mini Z domain | protein | 34 | 74% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.31 | 0.74 | 20 | empty |
| 2 | 60 | 0.30 | 0.75 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1051 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 739 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 703 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 7LUR · Stable Effector Functionless 2 (SEFL2) IgG1 Fc Scaffold Bound to a Minimized Version of… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01857
- Elsewhere: RCSB PDB 7LUR · PDBe 7LUR · UniProt P01857
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