MolNFT v1 · #181374 · protein

Structure of the cgas-like receptor human MB21D2

7LT1 · Protein MB21D2: “Structure of the cgas-like receptor human MB21D2”. X-ray diffraction, 1 ligand (SO4), 7 pockets (best druggability 0.75). MolNFT v1 #181374 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LT1
Type: protein
Length: 796 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein MB21D2
UniProt: Q8IYB1
Ligands: SO4
Pockets: 7 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein MB21D2	protein	403	48% helix, 19% strand	Q8IYB1
B	Protein MB21D2	protein	393	47% helix, 19% strand	Q8IYB1

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	623	0.75	0.81	59	empty
2	729	0.74	0.79	59	empty
3	841	0.73	0.78	77	empty
4	261	0.68	0.84	42	empty
5	127	0.50	0.80	17	empty

Interfaces

1 interface between chains.

A–B · 418 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 26 modified (engineered).

Compared structures

7LT1 · Structure of the cGAS-like receptor human MB21D2 · the same entry in another collection · chain A against A, TM-score 1.00
Q8IYB1 · AlphaFold monomer V2.0 prediction for protein MB21D2 (Q8IYB1) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IYB1
Elsewhere: RCSB PDB 7LT1 · PDBe 7LT1 · UniProt Q8IYB1

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