MolNFT v1 · #181330 · protein

Co-complex CYP46A1 with 7742 (SOTICLESTAT/TAK-935))

7LRL: “Co-complex CYP46A1 with 7742 (SOTICLESTAT/TAK-935))”. X-ray diffraction, 2 ligands (HEM, YBS). MolNFT v1 #181330 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LRL
Type: protein
Length: 436 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q9Y6A2
Ligands: HEM, YBS

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	436	—	Q9Y6A2

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
YBS · [4-oxidanyl-4-(phenylmethyl)piperidin-1-yl]-(2-pyridin-4-ylpyridin-3-yl)methanone · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7LRL · Co-complex CYP46A1 with 7742 (Soticlestat/TAK-935)) · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y6A2 · AlphaFold monomer V2.0 prediction for cholesterol 24-hydroxylase (Q9Y6A2) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y6A2
Elsewhere: RCSB PDB 7LRL · PDBe 7LRL · UniProt Q9Y6A2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.