MolNFT v1 · #181299 · protein

Crystal structure of a genetically encoded red fluorescent peroxynitrite biosensor, pnrfp

7LQO · Red fluorescent peroxynitrite biosensor pnrfp: “Crystal structure of a genetically encoded red fluorescent peroxynitrite biosensor, pnrfp”. X-ray diffraction, 2 ligands (NRQ, PO4), 2 pockets (best druggability 0.78). MolNFT v1…

PDB: 7LQO
Type: protein
Length: 229 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Red fluorescent peroxynitrite biosensor pnrfp
Ligands: NRQ, PO4
Pockets: 2 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Red fluorescent peroxynitrite biosensor pnrfp	protein	229	6% helix, 55% strand	—

Ligands and binding sites

NRQ · {(4Z)-4-(4-hydroxybenzylidene)-2-[3-(methylthio) propanimidoyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A
PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.78	0.96	34	NRQ
2	76	0.47	0.82	18	empty

Modifications

Observed in the structure: 2 cofactor, 1 modified (chromophore, nonstandard).

Compared structures

7LQO · Crystal structure of a genetically encoded red fluorescent peroxynitrite biosensor, pnRFP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7LQO · PDBe 7LQO

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