MolNFT v1 · #181298 · protein

Glucosamine-6-phosphate deaminase from H. influenzae

7LQN: “Glucosamine-6-phosphate deaminase from H. influenzae”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #181298 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LQN
Type: protein
Length: 3,132 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucosamine-6-phosphate deaminase
EC: 3.5.99.6
UniProt: Q4QP46
Pockets: 20 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L	Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	protein	261	43% helix, 17% strand	Q4QP46

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	996	0.81	0.82	98	empty
2	1012	0.80	0.82	102	empty
3	680	0.78	0.82	71	empty
4	594	0.77	0.83	61	empty
5	483	0.76	0.84	62	empty

Interfaces

24 interfaces between chains.

I–K · 523 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 522 Å² buried · 10 hydrogen bonds · protein-protein
G–J · 518 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 514 Å² buried · 6 hydrogen bonds · protein-protein
B–E · 503 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

7LQN · Glucosamine-6-phosphate Deaminase from H. influenzae · the same entry in another collection · chain J against J, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4QP46
Elsewhere: RCSB PDB 7LQN · PDBe 7LQN · UniProt Q4QP46

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