MolNFT v1 · #181226 · protein

Model of the HIV-1 GP41 membrane-proximal external region, transmembrane domain and cytoplasmic tail

7LOI · Transmembrane protein GP41: “Model of the HIV-1 GP41 membrane-proximal external region, transmembrane domain and cytoplasmic tail”. Solution nmr, 4 pockets (best druggability 0.79). MolNFT v1 #181226 on GenesisL1: 3D structure…

PDB: 7LOI
Type: protein
Length: 525 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transmembrane protein GP41
UniProt: A0A386YSI0
Pockets: 4 · best druggability 0.79

Structure

solution nmr · 1 distinct chain · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Transmembrane protein GP41	protein	175	76% helix, 0% strand	A0A386YSI0

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	858	0.79	0.81	54	empty
2	70	0.71	0.96	18	empty
3	72	0.33	0.75	11	empty
4	70	0.33	0.75	12	empty

Interfaces

3 interfaces between chains.

A–B · 2197 Å² buried · 8 hydrogen bonds · protein-protein
A–C · 2168 Å² buried · 23 hydrogen bonds · protein-protein
B–C · 2142 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

7LOI · Model of the HIV-1 gp41 membrane-proximal external region, transmembrane domain and… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A386YSI0
Elsewhere: RCSB PDB 7LOI · PDBe 7LOI · UniProt A0A386YSI0

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