MolNFT v1 · #181225 · protein

Structure of the HIV-1 GP41 transmembrane domain and cytoplasmic tail

7LOH · Transmembrane protein GP41: “Structure of the HIV-1 GP41 transmembrane domain and cytoplasmic tail”. Solution nmr, 7 pockets (best druggability 0.71). MolNFT v1 #181225 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LOH
Type: protein
Length: 474 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transmembrane protein GP41
UniProt: A0A386YSI0
Pockets: 7 · best druggability 0.71

Structure

solution nmr · 1 distinct chain · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Transmembrane protein GP41	protein	158	80% helix, 0% strand	A0A386YSI0

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	219	0.71	0.87	31	empty
2	121	0.54	0.82	19	empty
3	116	0.43	0.77	24	empty
4	100	0.37	0.75	17	empty
5	74	0.35	0.75	13	empty

Interfaces

3 interfaces between chains.

A–B · 1877 Å² buried · 9 hydrogen bonds · protein-protein
B–C · 1817 Å² buried · 8 hydrogen bonds · protein-protein
A–C · 1807 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

7LOH · Structure of the HIV-1 gp41 transmembrane domain and cytoplasmic tail · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A386YSI0
Elsewhere: RCSB PDB 7LOH · PDBe 7LOH · UniProt A0A386YSI0

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