MolNFT v1 · #180965 · protein

PEG10 ca-like C-terminal domain

7LGA · Retrotransposon-derived protein PEG10: “PEG10 ca-like C-terminal domain”. X-ray diffraction, 5 pockets (best druggability 0.76). MolNFT v1 #180965 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LGA
Type: protein
Length: 347 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Retrotransposon-derived protein PEG10
UniProt: Q86TG7
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 4 distinct chains · 70% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Retrotransposon-derived protein PEG10	protein	85	68% helix, 1% strand	Q86TG7
B	Retrotransposon-derived protein PEG10	protein	85	72% helix, 1% strand	Q86TG7
D	Retrotransposon-derived protein PEG10	protein	91	68% helix, 1% strand	Q86TG7
E	Retrotransposon-derived protein PEG10	protein	86	72% helix, 1% strand	Q86TG7

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	856	0.76	0.80	78	empty
2	141	0.54	0.81	19	empty
3	184	0.49	0.76	24	empty
4	122	0.47	0.78	20	empty
5	108	0.46	0.79	17	empty

Interfaces

4 interfaces between chains.

D–E · 621 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 588 Å² buried · 16 hydrogen bonds · protein-protein
A–E · 484 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 482 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

7LGA · PEG10 CA-like C-terminal domain · the same entry in another collection · chain E against E, TM-score 1.00
Q86TG7 · AlphaFold monomer V2.0 prediction for retrotransposon-derived protein PEG10 (Q86TG7) · a predicted model of the same protein · chain E against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86TG7
Elsewhere: RCSB PDB 7LGA · PDBe 7LGA · UniProt Q86TG7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.