MolNFT v1 · #180954 · protein
Human leukocyte antigen B*07:02 in complex with SARS-COV2 epitope iprrnvatl
7LFZ · HLA class I histocompatibility antigen, B-7 alpha chain: “Human leukocyte antigen B*07:02 in complex with SARS-COV2 epitope iprrnvatl”. X-ray diffraction, 5 pockets (best druggability 0.68). MolNFT v1 #180954 on GenesisL1: 3D…
- PDB
- 7LFZ
- Type
- protein
- Length
- 384 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, B-7 alpha chain; Beta-2-microglobulin; ORF1AB
- UniProt
- P01889, P61769, P0DTD1
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, B-7 alpha chain | protein | 275 | 27% helix, 40% strand | P01889 |
| B | Beta-2-microglobulin | protein | 100 | 0% helix, 49% strand | P61769 |
| C | ORF1AB | protein | 9 | 0% helix, 0% strand | P0DTD1 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 470 | 0.68 | 0.79 | 52 | empty |
| 2 | 158 | 0.47 | 0.77 | 24 | empty |
| 3 | 63 | 0.42 | 0.82 | 14 | empty |
| 4 | 55 | 0.37 | 0.80 | 14 | empty |
| 5 | 67 | 0.30 | 0.74 | 16 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1402 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 885 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7LFZ · Human leukocyte antigen B*07:02 in complex with SARS-CoV2 epitope IPRRNVATL · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P01889 · AlphaFold monomer V2.0 prediction for HLA class I histocompatibility antigen, B alpha… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01889
- Every structure of UniProt P61769
- Every structure of UniProt P0DTD1
- Elsewhere: RCSB PDB 7LFZ · PDBe 7LFZ · UniProt P01889 · UniProt P61769 · UniProt P0DTD1
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