MolNFT v1 · #18091 · protein
Ligand-binding domain of drosophila orphan nuclear receptor DHR38
1PDU · Nuclear hormone receptor HR38: “Ligand-binding domain of drosophila orphan nuclear receptor DHR38”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT v1 #18091 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1PDU
- Type
- protein
- Length
- 458 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear hormone receptor HR38
- UniProt
- P49869
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear hormone receptor HR38 | protein | 230 | 68% helix, 3% strand | P49869 |
| B | Nuclear hormone receptor HR38 | protein | 228 | 68% helix, 4% strand | P49869 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 284 | 0.67 | 0.83 | 49 | empty |
| 2 | 83 | 0.46 | 0.81 | 16 | empty |
| 3 | 90 | 0.42 | 0.78 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 479 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1PDU · Ligand-binding domain of Drosophila orphan nuclear receptor DHR38 · the same entry in another collection · chain A against A, TM-score 1.00
- P49869 · AlphaFold monomer V2.0 prediction for probable nuclear hormone receptor HR38 (P49869) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49869
- Elsewhere: RCSB PDB 1PDU · PDBe 1PDU · UniProt P49869
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