MolNFT v1 · #180905 · protein
Crystal structure of the first bromodomain (BD1) of human brdt bound to LRRK2-in-1
7LEM: “Crystal structure of the first bromodomain (BD1) of human brdt bound to LRRK2-in-1”. X-ray diffraction, 1 ligand (4K4). MolNFT v1 #180905 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LEM
- Type
- protein
- Length
- 216 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q58F21
- Ligands
- 4K4
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 108 | — | Q58F21 |
Ligands and binding sites
- 4K4 · 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one · ligand · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 10 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7LEM · Crystal structure of the first bromodomain (BD1) of human BRDT bound to LRRK2-IN-1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q58F21 · AlphaFold monomer V2.0 prediction for bromodomain testis-specific protein (Q58F21) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q58F21
- Elsewhere: RCSB PDB 7LEM · PDBe 7LEM · UniProt Q58F21
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