MolNFT v1 · #180783 · protein

Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-295

7LB0 · Transcription initiation factor tfiid subunit 1: “Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-295”. X-ray diffraction, 1 ligand (XXV), 3 pockets (best druggability 0.65). MolNFT v1 #180783 on…

PDB: 7LB0
Type: protein
Length: 248 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription initiation factor tfiid subunit 1
EC: 2.3.1.48, 2.7.11.1
UniProt: P21675
Ligands: XXV
Pockets: 3 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription initiation factor tfiid subunit 1 (EC 2.3.1.48, 2.7.11.1)	protein	248	70% helix, 0% strand	P21675

Ligands and binding sites

XXV · 1-{6-[(3R)-3-methylmorpholin-4-yl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl}cyclopropane-1-sulfonamide · ligand · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	404	0.65	0.78	42	XXV
2	76	0.44	0.80	17	empty
3	73	0.33	0.75	15	empty

Compared structures

7LB0 · Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-295 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21675
Elsewhere: RCSB PDB 7LB0 · PDBe 7LB0 · UniProt P21675

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.