MolNFT v1 · #180741 · protein

Crystal structure of a putative deoxyhypusine synthase from entamoeba histolytica

7L9R · Deoxyhypusine synthase, putative: “Crystal structure of a putative deoxyhypusine synthase from entamoeba histolytica”. X-ray diffraction, 1 ligand (CL), 4 pockets (best druggability 0.74). MolNFT v1 #180741 on GenesisL1: 3D…

PDB: 7L9R
Type: protein
Length: 562 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Deoxyhypusine synthase, putative
UniProt: C4LXB8
Ligands: CL
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Deoxyhypusine synthase, putative	protein	276	50% helix, 13% strand	C4LXB8
B	Deoxyhypusine synthase, putative	protein	286	47% helix, 14% strand	C4LXB8

Ligands and binding sites

CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	664	0.74	0.80	78	empty
2	101	0.37	0.75	20	CL
3	88	0.35	0.75	17	CL
4	51	0.27	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 1016 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

7L9R · Crystal Structure of a putative deoxyhypusine synthase from Entamoeba histolytica · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C4LXB8
Elsewhere: RCSB PDB 7L9R · PDBe 7L9R · UniProt C4LXB8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.