MolNFT v1 · #180717 · protein
BG505 SOSIP.V5.2 N241/N289 in complex with the polyclonal Fab pabc-3 from animal RH.33311 (WK26 time point)
7L8W · BG505 SOSIP.V5.2 N241/N289 - GP120: “BG505 SOSIP.V5.2 N241/N289 in complex with the polyclonal Fab pabc-3 from animal RH.33311 (WK26 time point)”. Electron microscopy, 3 ligands (NAG, MAN, BMA), 20 pockets (best druggability 0.80).…
- PDB
- 7L8W
- Type
- protein
- Length
- 1,926 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BG505 SOSIP.V5.2 N241/N289 - GP120; BG505 SOSIP.V5.2 N241/N289 - GP41; RH.33311 pabc-3…
- Ligands
- NAG, MAN, BMA
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 8 distinct chains · 25% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BG505 SOSIP.V5.2 N241/N289 - GP120 | protein | 440 | 17% helix, 41% strand | — |
| B | BG505 SOSIP.V5.2 N241/N289 - GP41 | protein | 132 | 64% helix, 2% strand | — |
| C | BG505 SOSIP.V5.2 N241/N289 - GP120 | protein | 438 | 16% helix, 42% strand | — |
| D | BG505 SOSIP.V5.2 N241/N289 - GP41 | protein | 133 | 70% helix, 3% strand | — |
| E | BG505 SOSIP.V5.2 N241/N289 - GP120 | protein | 439 | 14% helix, 43% strand | — |
| F | BG505 SOSIP.V5.2 N241/N289 - GP41 | protein | 132 | 70% helix, 7% strand | — |
| H | RH.33311 pabc-3 - heavy chain | protein | 109 | 3% helix, 44% strand | — |
| L | RH.33311 pabc-3 - light chain | protein | 103 | 0% helix, 49% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 73 copies · chains A, C, E, B, D, F
- MAN · alpha-D-mannopyranose · sugar · 10 copies · chains H, A, C, E
- BMA · beta-D-mannopyranose · sugar · 3 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 610 | 0.80 | 0.85 | 54 | empty |
| 2 | 643 | 0.78 | 0.84 | 84 | empty |
| 3 | 1084 | 0.77 | 0.80 | 116 | empty |
| 4 | 547 | 0.77 | 0.84 | 73 | empty |
| 5 | 835 | 0.77 | 0.81 | 89 | empty |
Interfaces
17 interfaces between chains.
- E–F · 2563 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 2545 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 2439 Ų buried · 17 hydrogen bonds · protein-protein
- D–F · 1084 Ų buried · 8 hydrogen bonds · protein-protein
- B–F · 1063 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 65 glycan, 36 disulfide (N-glycosylation, disulfide).
Compared structures
- 7L8W · BG505 SOSIP.v5.2 N241/N289 in complex with the polyclonal Fab pAbC-3 from animal Rh.33311… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7L8W · PDBe 7L8W
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