MolNFT v1 · #18069 · protein
Crystal structure of E.COLI chloramphenicol acetyltransferase type I at 2.5 ångström resolution
1PD5: “Crystal structure of E.COLI chloramphenicol acetyltransferase type I at 2.5 ångström resolution”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #18069 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1PD5
- Type
- protein
- Length
- 2,558 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloramphenicol acetyltransferase
- EC
- 2.3.1.28
- UniProt
- P62577
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 9 distinct chains · 32% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, G | Chloramphenicol acetyltransferase (EC 2.3.1.28) | protein | 213 | 33% helix, 31% strand | P62577 |
| B | Chloramphenicol acetyltransferase (EC 2.3.1.28) | protein | 216 | 31% helix, 31% strand | P62577 |
| E | Chloramphenicol acetyltransferase (EC 2.3.1.28) | protein | 215 | 30% helix, 32% strand | P62577 |
| F | Chloramphenicol acetyltransferase (EC 2.3.1.28) | protein | 212 | 32% helix, 31% strand | P62577 |
| H | Chloramphenicol acetyltransferase (EC 2.3.1.28) | protein | 216 | 31% helix, 31% strand | P62577 |
| I | Chloramphenicol acetyltransferase (EC 2.3.1.28) | protein | 214 | 32% helix, 31% strand | P62577 |
| J | Chloramphenicol acetyltransferase (EC 2.3.1.28) | protein | 211 | 32% helix, 32% strand | P62577 |
| K | Chloramphenicol acetyltransferase (EC 2.3.1.28) | protein | 212 | 32% helix, 31% strand | P62577 |
| L | Chloramphenicol acetyltransferase (EC 2.3.1.28) | protein | 210 | 32% helix, 31% strand | P62577 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 711 | 0.80 | 0.84 | 66 | empty |
| 2 | 681 | 0.78 | 0.82 | 67 | empty |
| 3 | 596 | 0.77 | 0.83 | 71 | empty |
| 4 | 474 | 0.77 | 0.85 | 57 | empty |
| 5 | 678 | 0.77 | 0.82 | 76 | empty |
Interfaces
17 interfaces between chains.
- K–L · 1173 Ų buried · 21 hydrogen bonds · protein-protein
- G–I · 1170 Ų buried · 18 hydrogen bonds · protein-protein
- D–E · 1167 Ų buried · 19 hydrogen bonds · protein-protein
- J–L · 1165 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 1163 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 1PD5 · Crystal structure of E.coli chloramphenicol acetyltransferase type I at 2.5 Angstrom… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62577
- Elsewhere: RCSB PDB 1PD5 · PDBe 1PD5 · UniProt P62577
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.