MolNFT v1 · #18064 · protein

Structure of tata-binding protein

1PCZ: “Structure of tata-binding protein”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #18064 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1PCZ
Type: protein
Length: 366 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tata-binding protein
UniProt: P62001
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tata-binding protein	protein	183	27% helix, 37% strand	P62001

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	142	0.59	0.84	46	empty
2	148	0.46	0.77	24	empty
3	110	0.43	0.78	25	empty

Interfaces

1 interface between chains.

A–B · 1563 Å² buried · 21 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1PCZ · Structure of tata-binding protein · the same entry in another collection · chain A against A, TM-score 1.00
P62001 · AlphaFold monomer V2.0 prediction for tata-box-binding protein (P62001) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62001
Elsewhere: RCSB PDB 1PCZ · PDBe 1PCZ · UniProt P62001

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