MolNFT v1 · #180541 · protein

Bacterial cellulose synthase bcsb hexamer

7L2Z · Cyclic di-gmp-binding protein: “Bacterial cellulose synthase bcsb hexamer”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #180541 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7L2Z
Type: protein
Length: 3,866 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cyclic di-gmp-binding protein
UniProt: P37652
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 6 distinct chains · 13% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Cyclic di-gmp-binding protein	protein	645	12% helix, 29% strand	P37652
A	Cyclic di-gmp-binding protein	protein	619	15% helix, 30% strand	P37652
C	Cyclic di-gmp-binding protein	protein	647	13% helix, 31% strand	P37652
D	Cyclic di-gmp-binding protein	protein	645	11% helix, 33% strand	P37652
E	Cyclic di-gmp-binding protein	protein	646	12% helix, 32% strand	P37652
F	Cyclic di-gmp-binding protein	protein	664	12% helix, 31% strand	P37652

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	957	0.84	0.86	129	empty
2	1102	0.82	0.84	105	empty
3	1073	0.82	0.83	90	empty
4	738	0.80	0.84	60	empty
5	680	0.79	0.84	59	empty

Interfaces

8 interfaces between chains.

E–F · 3772 Å² buried · 59 hydrogen bonds · protein-protein
D–E · 3649 Å² buried · 66 hydrogen bonds · protein-protein
B–C · 3528 Å² buried · 43 hydrogen bonds · protein-protein
C–D · 3526 Å² buried · 40 hydrogen bonds · protein-protein
B–A · 3427 Å² buried · 45 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

7L2Z · Bacterial cellulose synthase BcsB hexamer · the same entry in another collection · chain F against F, TM-score 1.00
P37652 · AlphaFold monomer V2.0 prediction for cyclic di-gmp-binding protein (P37652) · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37652
Elsewhere: RCSB PDB 7L2Z · PDBe 7L2Z · UniProt P37652

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