MolNFT v1 · #18050 · protein

PROCARICAIN

1PCI: “PROCARICAIN”. X-ray diffraction, 6 pockets (best druggability 0.73). MolNFT v1 #18050 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1PCI
Type: protein
Length: 933 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Procaricain
EC: 3.4.22.6
UniProt: P10056
Pockets: 6 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Procaricain (EC 3.4.22.6)	protein	311	33% helix, 19% strand	P10056

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	539	0.73	0.81	52	empty
2	532	0.70	0.79	42	empty
3	201	0.50	0.77	32	empty
4	80	0.36	0.76	17	empty
5	63	0.35	0.77	12	empty

Interfaces

3 interfaces between chains.

A–C · 746 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 610 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 291 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

1PCI · PROCARICAIN · the same entry in another collection · chain A against A, TM-score 1.00
P10056 · AlphaFold monomer V2.0 prediction for caricain (P10056) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10056
Elsewhere: RCSB PDB 1PCI · PDBe 1PCI · UniProt P10056

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