Structure of amh bound to AMHR2-ecd

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 45% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A, B
• SO4 · Sulfate ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 950 Ų buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 7L0J · Structure of AMH bound to AMHR2-ECD · the same entry in another collection · chain A against A, TM-score 1.00
• P03971 · AlphaFold monomer V2.0 prediction for muellerian-inhibiting factor (P03971) · a predicted model of the same protein · chain A against A, TM-score 0.89
• Q16671 · AlphaFold monomer V2.0 prediction for anti-muellerian hormone type-2 receptor (Q16671) · a predicted model of the same protein · chain B against A, TM-score 0.88

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P03971
• Every structure of UniProt Q16671
• Elsewhere: RCSB PDB 7L0J · PDBe 7L0J · UniProt P03971 · UniProt Q16671