MolNFT v1 · #180373 · protein

Crystal structure of rar-related orphan receptor C (nhis-RORGT(244- 487)-L6-SRC1(678-692)) in complex with {3,5-dichloro-4-[4-methoxy-3- (propan-2-YL)PHENOXY]PHENYL}METHANOL

7KXF · Nuclear receptor ror-gamma, nuclear receptor coactivator 1…: “Crystal structure of rar-related orphan receptor C (nhis-RORGT(244- 487)-L6-SRC1(678-692)) in complex with…”. X-ray diffraction, 1 ligand (Z7I), 3 pockets (best…

PDB: 7KXF
Type: protein
Length: 253 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear receptor ror-gamma, nuclear receptor coactivator 1 chimera
EC: 2.3.1.48
UniProt: P51449, Q15788
Ligands: Z7I
Pockets: 3 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear receptor ror-gamma, nuclear receptor coactivator 1 chimera (EC 2.3.1.48)	protein	253	72% helix, 4% strand	P51449, Q15788

Ligands and binding sites

Z7I · N-(3,5-dichloro-4-{[6-methoxy-5-(propan-2-yl)pyridin-3-yl]oxy}phenyl)-2-[1-(methylsulfonyl)piperidin-4-yl]acetamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	344	0.82	0.91	37	Z7I
2	105	0.47	0.80	18	empty
3	80	0.40	0.78	15	empty

Compared structures

7KXF · Crystal structure of rar-related orphan receptor C (nhis-RORGT(244-487)-L6-SRC1(678-692))… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51449
Every structure of UniProt Q15788
Elsewhere: RCSB PDB 7KXF · PDBe 7KXF · UniProt P51449 · UniProt Q15788

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