MolNFT v1 · #180124 · protein

Structure of the H-lobe of yeast ckm

7KPW · Mediator of RNA polymerase II transcription subunit 12: “Structure of the H-lobe of yeast ckm”. Electron microscopy, 7 pockets (best druggability 0.79). MolNFT v1 #180124 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7KPW
Type: protein
Length: 865 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mediator of RNA polymerase II transcription subunit 12
UniProt: P25648
Pockets: 7 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Mediator of RNA polymerase II transcription subunit 12	protein	865	72% helix, 0% strand	P25648

Pockets

7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	820	0.79	0.83	111	empty
2	992	0.73	0.77	108	empty
3	652	0.73	0.80	79	empty
4	352	0.72	0.84	63	empty
5	381	0.66	0.80	66	empty

Compared structures

7KPW · Structure of the H-lobe of yeast CKM · the same entry in another collection · chain C against C, TM-score 1.00
P25648 · AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit… · a predicted model of the same protein · chain C against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25648
Elsewhere: RCSB PDB 7KPW · PDBe 7KPW · UniProt P25648

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