MolNFT v1 · #180112 · protein

Crystal structure of the spop math domain in complex with a fragment of PDX1

7KPK · Speckle-type poz protein: “Crystal structure of the spop math domain in complex with a fragment of PDX1”. X-ray diffraction, 1 pocket (best druggability 0.36). MolNFT v1 #180112 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7KPK
Type: protein
Length: 141 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Speckle-type poz protein; PDX1 peptide
UniProt: D6RDG8
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Speckle-type poz protein	protein	134	8% helix, 54% strand	D6RDG8
B	PDX1 peptide	protein	7	0% helix, 14% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.36	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 350 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

7KPK · Crystal structure of the SPOP MATH domain in complex with a fragment of Pdx1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D6RDG8
Elsewhere: RCSB PDB 7KPK · PDBe 7KPK · UniProt D6RDG8

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