MolNFT v1 · #180082 · protein
Structure of upper tn CA2+ free (rotated) and lower tn CA2+ bound cardiac native thin filament at PCA=5.8
7KON · Actin, alpha skeletal muscle: “Structure of upper tn CA2+ free (rotated) and lower tn CA2+ bound cardiac native thin filament at PCA=5.8”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #180082 on GenesisL1: 3D…
- PDB
- 7KON
- Type
- protein
- Length
- 7,717 residues
- Chains
- 29
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle; Tropomyosin alpha-1 chain; Troponin T, cardiac muscle…
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 8 distinct chains · 70% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | Actin, alpha skeletal muscle | protein | 375 | 41% helix, 18% strand | — |
| P, Q, W, X | Tropomyosin alpha-1 chain | protein | 274 | 98% helix, 0% strand | — |
| R, S, Y, Z | Tropomyosin alpha-1 chain | protein | 29 | 90% helix, 0% strand | — |
| T | Troponin T, cardiac muscle | protein | 126 | 87% helix, 0% strand | — |
| U | Troponin I, cardiac muscle | protein | 170 | 72% helix, 0% strand | — |
| V, c | Troponin C | protein | 160 | 49% helix, 4% strand | — |
| a | Troponin T, cardiac muscle | protein | 138 | 87% helix, 0% strand | — |
| b | Troponin I, cardiac muscle | protein | 126 | 76% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1027 | 0.85 | 0.86 | 119 | empty |
| 2 | 914 | 0.84 | 0.86 | 97 | empty |
| 3 | 986 | 0.84 | 0.85 | 99 | empty |
| 4 | 890 | 0.83 | 0.85 | 104 | empty |
| 5 | 715 | 0.83 | 0.87 | 93 | empty |
Interfaces
86 interfaces between chains.
- W–X · 6925 Ų buried · 26 hydrogen bonds · protein-protein
- P–Q · 6919 Ų buried · 42 hydrogen bonds · protein-protein
- T–U · 2347 Ų buried · 40 hydrogen bonds · protein-protein
- a–b · 2323 Ų buried · 43 hydrogen bonds · protein-protein
- b–c · 2052 Ų buried · 43 hydrogen bonds · protein-protein
Compared structures
- 7KON · Structure of upper Tn Ca2+ free (rotated) and lower Tn Ca2+ bound cardiac native thin… · the same entry in another collection · chain N against N, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7KON · PDBe 7KON
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