MolNFT v1 · #180068 · protein
Structure of the native cardiac thin filament at PCA=5.8 having upper tn in CA2+ free state and lower tn in CA2+ bound state
7KO7 · Actin, alpha skeletal muscle: “Structure of the native cardiac thin filament at PCA=5.8 having upper tn in CA2+ free state and lower tn in…”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #180068 on GenesisL1…
- PDB
- 7KO7
- Type
- protein
- Length
- 7,717 residues
- Chains
- 29
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle; Tropomyosin alpha-1 chain; Troponin T, cardiac muscle…
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 8 distinct chains · 70% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | Actin, alpha skeletal muscle | protein | 375 | 41% helix, 18% strand | — |
| P, Q, W, X | Tropomyosin alpha-1 chain | protein | 274 | 98% helix, 0% strand | — |
| R, S, Y, Z | Tropomyosin alpha-1 chain | protein | 29 | 90% helix, 0% strand | — |
| T | Troponin T, cardiac muscle | protein | 126 | 85% helix, 0% strand | — |
| U | Troponin I, cardiac muscle | protein | 170 | 68% helix, 0% strand | — |
| V, c | Troponin C | protein | 160 | 54% helix, 4% strand | — |
| a | Troponin T, cardiac muscle | protein | 138 | 89% helix, 0% strand | — |
| b | Troponin I, cardiac muscle | protein | 126 | 74% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1098 | 0.85 | 0.86 | 124 | empty |
| 2 | 1123 | 0.85 | 0.86 | 123 | empty |
| 3 | 991 | 0.85 | 0.86 | 105 | empty |
| 4 | 878 | 0.83 | 0.86 | 102 | empty |
| 5 | 811 | 0.81 | 0.84 | 84 | empty |
Interfaces
89 interfaces between chains.
- P–Q · 6921 Ų buried · 42 hydrogen bonds · protein-protein
- W–X · 6916 Ų buried · 26 hydrogen bonds · protein-protein
- T–U · 2250 Ų buried · 35 hydrogen bonds · protein-protein
- a–b · 2232 Ų buried · 40 hydrogen bonds · protein-protein
- b–c · 1988 Ų buried · 45 hydrogen bonds · protein-protein
Compared structures
- 7KO7 · Structure of the native cardiac thin filament at pCa=5.8 having upper Tn in Ca2+ free… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7KO7 · PDBe 7KO7
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