MolNFT v1 · #180066 · protein
Structure of cardiac native thin filament at PCA=5.8 having upper and lower troponins in CA2+ bound state
7KO5 · Actin, alpha skeletal muscle: “Structure of cardiac native thin filament at PCA=5.8 having upper and lower troponins in CA2+ bound state”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #180066 on GenesisL1: 3D…
- PDB
- 7KO5
- Type
- protein
- Length
- 7,661 residues
- Chains
- 29
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle; Tropomyosin alpha-1 chain; Troponin T, cardiac muscle…
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 6 distinct chains · 69% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | Actin, alpha skeletal muscle | protein | 375 | 41% helix, 18% strand | — |
| P, Q, W, X | Tropomyosin alpha-1 chain | protein | 274 | 98% helix, 0% strand | — |
| R, S, Y, Z | Tropomyosin alpha-1 chain | protein | 29 | 90% helix, 0% strand | — |
| T, a | Troponin T, cardiac muscle | protein | 126 | 88% helix, 0% strand | — |
| U, b | Troponin I, cardiac muscle | protein | 126 | 75% helix, 0% strand | — |
| V, c | Troponin C | protein | 160 | 58% helix, 4% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 882 | 0.85 | 0.87 | 94 | empty |
| 2 | 901 | 0.84 | 0.86 | 107 | empty |
| 3 | 1035 | 0.82 | 0.83 | 106 | empty |
| 4 | 1087 | 0.82 | 0.83 | 99 | empty |
| 5 | 1104 | 0.81 | 0.83 | 91 | empty |
Interfaces
89 interfaces between chains.
- W–X · 6903 Ų buried · 42 hydrogen bonds · protein-protein
- P–Q · 6902 Ų buried · 42 hydrogen bonds · protein-protein
- T–U · 2367 Ų buried · 37 hydrogen bonds · protein-protein
- a–b · 2322 Ų buried · 35 hydrogen bonds · protein-protein
- U–V · 2091 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 7KO5 · Structure of cardiac native thin filament at pCa=5.8 having upper and lower troponins in… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7KO5 · PDBe 7KO5
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