MolNFT v1 · #179911 · protein
Crystal structure of PLEKHA7 pH domain biding SO4
7KJO · Pleckstrin homology domain-containing family a member 7: “Crystal structure of PLEKHA7 pH domain biding SO4”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.37). MolNFT v1 #179911 on GenesisL1: 3D structure…
- PDB
- 7KJO
- Type
- protein
- Length
- 206 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pleckstrin homology domain-containing family a member 7
- UniProt
- Q6IQ23
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pleckstrin homology domain-containing family a member 7 | protein | 101 | 18% helix, 46% strand | Q6IQ23 |
| B | Pleckstrin homology domain-containing family a member 7 | protein | 105 | 23% helix, 42% strand | Q6IQ23 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.37 | 0.74 | 21 | empty |
| 2 | 81 | 0.35 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 636 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7KJO · crystal structure of PLEKHA7 PH domain biding SO4 · the same entry in another collection · chain A against A, TM-score 1.00
- Q6IQ23 · AlphaFold monomer V2.0 prediction for pleckstrin homology domain- containing family a… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6IQ23
- Elsewhere: RCSB PDB 7KJO · PDBe 7KJO · UniProt Q6IQ23
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