MolNFT v1 · #179886 · protein
Plasmodium falciparum rhoph complex in soluble form
7KIY · Cytoadherence linked asexual protein 3: “Plasmodium falciparum rhoph complex in soluble form”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #179886 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KIY
- Type
- protein
- Length
- 2,376 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytoadherence linked asexual protein 3; High molecular weight rhoptry protein-2; High…
- UniProt
- Q8I060, A0A024X9S2
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 3 distinct chains · 50% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytoadherence linked asexual protein 3 | protein | 1169 | 53% helix, 2% strand | — |
| B | High molecular weight rhoptry protein-2 | protein | 516 | 56% helix, 0% strand | Q8I060 |
| C | High molecular weight rhoptry protein 3 | protein | 691 | 42% helix, 2% strand | A0A024X9S2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 812 | 0.87 | 0.90 | 96 | empty |
| 2 | 481 | 0.79 | 0.87 | 54 | empty |
| 3 | 657 | 0.79 | 0.84 | 69 | empty |
| 4 | 682 | 0.78 | 0.83 | 80 | empty |
| 5 | 463 | 0.77 | 0.85 | 59 | empty |
Interfaces
2 interfaces between chains.
- A–C · 4061 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 2437 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
- 7KIY · Plasmodium falciparum RhopH complex in soluble form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8I060
- Every structure of UniProt A0A024X9S2
- Elsewhere: RCSB PDB 7KIY · PDBe 7KIY · UniProt Q8I060 · UniProt A0A024X9S2
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