MolNFT v1 · #179874 · protein
Crystal structure of the mouse lipin-1 M-lip domain with zinc
7KIL · Isoform 2 of phosphatidate phosphatase LPIN1: “Crystal structure of the mouse lipin-1 M-lip domain with zinc”. X-ray diffraction, 2 ligands (ZN, CL), 1 pocket (best druggability 0.35). MolNFT v1 #179874 on GenesisL1: 3D structure…
- PDB
- 7KIL
- Type
- protein
- Length
- 174 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 2 of phosphatidate phosphatase LPIN1
- UniProt
- Q91ZP3
- Ligands
- ZN, CL
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 2 of phosphatidate phosphatase LPIN1 | protein | 88 | 48% helix, 14% strand | Q91ZP3 |
| B | Isoform 2 of phosphatidate phosphatase LPIN1 | protein | 86 | 49% helix, 14% strand | Q91ZP3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.35 | 0.76 | 19 | ZN |
Interfaces
1 interface between chains.
- A–B · 1290 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7KIL · Crystal structure of the mouse lipin-1 M-Lip domain with zinc · the same entry in another collection · chain A against A, TM-score 1.00
- Q91ZP3 · AlphaFold monomer V2.0 prediction for phosphatidate phosphatase LPIN1 (Q91ZP3) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q91ZP3
- Elsewhere: RCSB PDB 7KIL · PDBe 7KIL · UniProt Q91ZP3
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