The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1 (sf-1)

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 2% strand (DSSP).

Ligands and binding sites

• WES · (2S)-3-{[(S)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy) phosphoryl]oxy}propane-1,2-diyl (9e,9'e)di-octadec-9-enoate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 469 Ų buried · 4 hydrogen bonds · protein-protein

Compared structures

• 7KHT · The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear… · the same entry in another collection · chain A against A, TM-score 1.00
• Q13285 · AlphaFold monomer V2.0 prediction for steroidogenic factor 1 (Q13285) · a predicted model of the same protein · chain A against A, TM-score 0.96
• Q9UBK2 · AlphaFold monomer V2.0 prediction for peroxisome proliferator- activated receptor gamma… · a predicted model of the same protein · chain B against A, TM-score 0.53

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q13285
• Every structure of UniProt Q9UBK2
• Elsewhere: RCSB PDB 7KHT · PDBe 7KHT · UniProt Q13285 · UniProt Q9UBK2