MolNFT v1 · #179838 · protein
Crystal structure of kit kinase domain with a small molecule inhibitor, PLX9486 (bezuclastinib) in the dfg-in state
7KHK: “Crystal structure of kit kinase domain with a small molecule inhibitor, PLX9486 (bezuclastinib) in the dfg-in…”. X-ray diffraction, 1 ligand (WEJ). MolNFT v1 #179838 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KHK
- Type
- protein
- Length
- 557 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Ligands
- WEJ
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 291 | — | — |
| B | — | protein | 266 | — | — |
Ligands and binding sites
- WEJ · 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7KHK · Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX9486… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7KHK · PDBe 7KHK
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