MolNFT v1 · #179758 · protein
Cryo-electron microscopy structure of the heavy metal efflux pump cusa in a homogeneous binding COPPER(1) state
7KF6 · Cation efflux system protein cusa: “Cryo-electron microscopy structure of the heavy metal efflux pump cusa in a homogeneous binding COPPER(1)…”. Electron microscopy, 1 ligand (CU1), 20 pockets (best druggability 0.85). MolNFT v1…
- PDB
- 7KF6
- Type
- protein
- Length
- 3,045 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cation efflux system protein cusa
- UniProt
- P38054
- Ligands
- CU1
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 51% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Cation efflux system protein cusa | protein | 1015 | 51% helix, 17% strand | P38054 |
Ligands and binding sites
- CU1 · Copper (I) ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1098 | 0.85 | 0.86 | 90 | empty |
| 2 | 1194 | 0.84 | 0.85 | 108 | empty |
| 3 | 755 | 0.84 | 0.87 | 83 | empty |
| 4 | 1063 | 0.80 | 0.81 | 106 | empty |
| 5 | 1042 | 0.80 | 0.81 | 94 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3266 Ų buried · 32 hydrogen bonds · protein-protein
- B–C · 3233 Ų buried · 32 hydrogen bonds · protein-protein
- A–C · 3232 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 7KF6 · Cryo-electron microscopy structure of the heavy metal efflux pump CusA in a homogeneous… · the same entry in another collection · chain A against A, TM-score 1.00
- P38054 · AlphaFold monomer V2.0 prediction for cation efflux system protein cusa (P38054) · a predicted model of the same protein · chain C against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38054
- Elsewhere: RCSB PDB 7KF6 · PDBe 7KF6 · UniProt P38054
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