MolNFT v1 · #179757 · protein
Cryo-electron microscopy structure of the heavy metal efflux pump cusa in the symmetric closed state
7KF5 · Cation efflux system protein cusa: “Cryo-electron microscopy structure of the heavy metal efflux pump cusa in the symmetric closed state”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #179757 on GenesisL1: 3D…
- PDB
- 7KF5
- Type
- protein
- Length
- 3,075 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cation efflux system protein cusa
- UniProt
- P38054
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 52% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Cation efflux system protein cusa | protein | 1025 | 52% helix, 17% strand | P38054 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 839 | 0.86 | 0.89 | 78 | empty |
| 2 | 874 | 0.86 | 0.88 | 83 | empty |
| 3 | 860 | 0.86 | 0.88 | 80 | empty |
| 4 | 467 | 0.76 | 0.85 | 49 | empty |
| 5 | 468 | 0.76 | 0.85 | 47 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2786 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 2775 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 2773 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 7KF5 · Cryo-electron microscopy structure of the heavy metal efflux pump CusA in the symmetric… · the same entry in another collection · chain A against A, TM-score 1.00
- P38054 · AlphaFold monomer V2.0 prediction for cation efflux system protein cusa (P38054) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38054
- Elsewhere: RCSB PDB 7KF5 · PDBe 7KF5 · UniProt P38054
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